Determining the efficacy of mycotoxin mitigators: In vitro vs In vivo

Commercial marketing of feed additives to prevent mycotoxicosis began about 40 years ago and is now a major industry. However, the challenge for suppliers has been proving product efficacy. Most methodology includes in vitro binding assays with individual purified mycotoxins, but extrapolating in vitro results to actual field conditions may not prove accurate. As a result, a more accurate method for testing product efficiency may be through in vivo studies. Most methodology includes in vitro bi